منابع مشابه
50-Year Anniversary of Sliding Filament
In this issue of the Journal we mark a milestone in physiology , the 50th anniversary of the publication in Nature Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation. Nature. 173:973–976) which formulated the sliding filament hypothesis of muscle contraction. Two historical reviews remind us of the significance this early work. One, by A...
متن کاملFifty years of muscle and the sliding filament hypothesis.
This review describes the early beginnings of X-ray diffraction work on muscle structure and the contraction mechanism in the MRC Unit in the Cavendish Laboratory, Cambridge, and later work in the MRC Molecular Biology Laboratory in Hills Road, Cambridge, where the author worked for many years, and elsewhere. The work has depended heavily on instrumentation development, for which the MRC labora...
متن کاملThe Sliding Filament Model
This review will describe the investigation of the mechanism of muscle contraction and cell motility from 1972 to the present. The preceding article in this issue by Andrew Szent-Gyorgyi covers the period up to 1972. In 1972 the field of actomyosin interactions was summarized in a conference at Cold Spring Harbor, published in the Cold Spring Harbor Symposia on Quantitative Biology XXXVII, 1973...
متن کاملThe Sliding Filament Model: 1972–2004
This review will describe the investigation of the mechanism of muscle contraction and cell motility from 1972 to the present. The preceding article in this issue by Andrew Szent-Gyorgyi covers the period up to 1972. In 1972 the field of actomyosin interactions was summarized in a conference at Cold Spring Harbor, published in the Cold Spring Harbor Symposia on Quantitative Biology XXXVII, 1973...
متن کاملMyosin filament sliding through the Z-disc relates striated muscle fibre structure to function.
Striated muscle contraction requires intricate interactions of microstructures. The classic textbook assumption that myosin filaments are compressed at the meshed Z-disc during striated muscle fibre contraction conflicts with experimental evidence. For example, myosin filaments are too stiff to be compressed sufficiently by the muscular force, and, unlike compressed springs, the muscle fibres d...
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ژورنال
عنوان ژورنال: Nature
سال: 2004
ISSN: 0028-0836,1476-4679
DOI: 10.1038/429145a